I have read most of the responses and all made relevant points about the senior management will, long term view, staff training and awareness. One point I do not see being considered is - The size and scale of the organization and its processes. I have worked in both start-up as well as in an MNC like IBM and one thing that stands out is the need for process flexibility in a start-ups vs the process conformity required in bigger teams and companies I think six sigma is helpful where the process conformity and highly defined process will derive benefit for businesses. Areas where process flexibility needs to be high and there is a high degree of change anticipated due to business growth, applying six sigma techniques will result in very short term benefits For companies that are in the early stages of growth, a lot of flexibility and agility is required as part of its processes. I think this is a key factor to decide whether a six sigma management and techniques could be applied at that point or not. Level of process conformity required and organization/business maturity is often, in my experience, a key determinant on whether you would adopt six sigma management and techniques or not. Best regards, Sireesha Jajala