What kind of six sigma tools can be used for an effective kickoff and running of the business? What kind of basic methodologies may be used? I am sure not all would be applicable. Can anyone guide me on this?

Interesting question.

There is actually a whole community that focuses on the application of all design tools to business and other areas. Try looking up design thinking to see what you find.

However, if I were to select a basic tool, then it would be FMEA. In business I think you need to think of all the things that could go wrong and be ready for them. FMEA hekp you do that. If you need help comming up with more ideas, then HAZOPs.