5 why analysis helps to understand the underlying root cause due to which a problem is occurring, Is/Is not analysis can be used for root cause identification however it can also be used to define a complex problem. The Is/ Is not matrix helps to separate the factors that are not the problem. This helps to narrow down the scope of the problem and focus on the problem area.
In a why why analysis each cause is further studied for factors that make the cause occur. Is/Is not analysis on other hand is based on getting to the most relevant factor by theory of elimination. Of course the elimination has to be done based on certain validation.
an example is attached.